T-cell surface glycoprotein CD3 epsilon chain

产品名称	T-cell surface glycoprotein CD3 epsilon chain
产品货号	DTD0073
产品规格
价格

产品详情

名称	T-cell surface glycoprotein CD3 epsilon chain
纯度	>90%
内毒素	<1 EU/μg
宿主细胞	HEK293
序列	MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI
基因名	CD3E
Uniprot ID	P07766
物种	Homo sapiens(Human)
产品性状	Liquid
缓冲液	1×PBS，pH7.4
储存方式	-80 ℃ packaging and storage to avoid repeated freezing and thawing.
SDS-PAGE &WB

产品说明书产品说明书

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

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发货时间：确认订单并完成付款后1~2个工作日内安排发货。
发货方式：冰袋或干冰。