| 产品名称 | Mouse Anti DXd Antibody, mAb |
| 靶点 | DXd |
| 类型 | Monoclonal |
| 产品货号 | DTA0031 |
| 产品规格 | |
| 价格 |
| 浓度 | 0.5 mg/mL |
| 免疫宿主 | Mouse |
| 免疫原 | DXd conjugated to keyhole limpet haemocyanin(KLH) |
| 克隆号 | 1M2F3 |
| 亚型 | IgG1 |
| 纯化方法 | Purified by Protein A |
| 特异性 | This antibody recognizes DXd and DXd structurally similar molecules. The antibody can bind to DS-8201. |
| 验证应用平台 | ELISA |
| 缓冲液 | 1×PBS, pH7.4, containing 0.05% BSA, 50% glycerol and 0.03% Proclin 300. |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
| 应用 | ELISA |
| 推荐用量 | 0.00005-1 µg/mL |
The DXd conjugated Trastuzumab ELISA assay is developed by using Mouse Anti DXd Antibody, mAb (Cat:DTA0031) and Goat Anti Mouse IgG Antibody[HRP], mAb as the capture and detection antibodies.
| DTA0031 | |
| EC50 | 9.507 ng/mL |
Mouse Anti DXd Antibody, mAb (Cat:DTA0031) binds with DS-8201.
Coating antigen: DS-8201, 0.1 µg
Mouse Anti DXd Antibody, mAb (Cat:DTA0031) dilution start from 1000 ng/mL.
DXd is a derivative of exatecan (DX8951f), a compound with increased activity and improved solubility compared to CPT, and described not to be an ABCC2 or ABCG1 substrate. DXd was used in several proprietary ADC programs, such as DS-8201a (Enhertu), U3-1402 and DS-6157a, conjugated at DAR8 and DS-1062a and DS-7300a conjugated at lower DAR (4) to limit their toxicity, that are either approved by the FDA (DS-8201a) or currently under clinical evaluation. Although the DXd payload presented lower passive membrane permeability than exatecan mesylate, it was found to be less myelotoxic and was therefore also selected for its improved safety profile.
The anti-payload antibody is a useful reagent in ADC research by quantifying and monitoring drug levels or accumulations in tumor tissue, and more. It can be used in PK, PD analysis and ELISA.
南京德泰生物工程有限公司 Nanjing Detai Bioengineering Co.,Ltd. ©2024 All Rights Reserved
苏ICP备2021019379号-1 | 网站地图 | 用户协议 | 隐私政策
