| 名称 | Mouse Anti DXd Antibody[HRP], mAb |
| 类型 | Monoclonal |
| 标记 | Horseradish peroxidase (HRP) |
| 免疫宿主 | Mouse |
| 免疫原 | DXd conjugated to keyhole limpet haemocyanin(KLH) |
| 特异性 | This antibody recognizes DXd and DXd structurally similar molecules. The antibody can bind to DS-8201. |
| 亚型 | IgG1, λ |
| 状态 | Liquid |
| 缓冲液 | 1×PBS, pH7.4, containing 0.05% BSA, 50% glycerol and 0.03% Proclin 300. |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
| 验证应用平台 | ELISA |
| 推荐稀释比 | 0.1-2 µg/ml |
DXd is a cell microtubule dynamics inhibitor and a soft sponge like anti-tumor drug. ADC loaded with DXd has a strong bystander effect and good clinical efficacy. Due to the release of payload after ADC administration, there is an increase in unbound payload and changes in ADC composition (i.e. DAR distribution). In order to address the challenges and difficulties in ADC drug PK analysis, a high-quality and high affinity anti DXd payload antibody can be used for ADC PK detection and DAR value analysis, which helps evaluate ADC efficacy, assess payload exposure at target sites, and is crucial for providing overall evaluation such as ADC stability.
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