| 名称 | Rabbit Anti Exatecan Antibody, mAb |
| 类型 | Monoclonal |
| 免疫宿主 | Rabbit |
| 免疫原 | Exatecan conjugated to keyhole limpet haemocyanin(KLH) |
| 亚型 | IgG |
| 纯化方法 | Purified by Protein A |
| 特异性 | This antibody recognizes Exatecan and Exatecan structurally similar molecules. |
| 验证应用平台 | ELISA |
| 缓冲液 | 1×PBS, pH7.4, containing 0.1% BSA, 50% glycerol and 0.03% Proclin 300. |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
| 应用 | ELISA |
| 推荐用量 | 0.1-2 µg/ml |
Rabbit Anti Exatecan Antibody, mAb binds with BSA-Exatecan conjugate. Coating antigen: BSA-Exatecan conjugate, 1 µg/ml, 100 µl/well. Rabbit Anti Exatecan Antibody, mAb dilution start from 1000 ng/ml. EC50= 7.79 ng/ml.
The competitive ELISA assay is developed by using free Exatecan block the binding of Rabbit Anti Exatecan Antibody, mAb to BSA-Exatecan conjugate.
Coating antigen: BSA-DXd conjugate, 0.1 µg/ml, 100 µl/well
Detection Antibody : Rabbit Anti Exatecan Antibody, mAb, 50ng/ml 50ul/well
Free Exatecan dilution start from 10000 ng/ml.
Exatecan is a potent, water-soluble synthetic analog of the topoisomerase I inhibitor camptothecin. It demonstrates superior stability and anticancer activity by stabilizing the topoisomerase I-DNA complex, leading to lethal DNA damage during replication. Its improved solubility profile over natural analogs like SN-38 makes it a more versatile payload for Antibody-Drug Conjugates (ADCs), enabling higher drug-to-antibody ratios and enhanced therapeutic efficacy.
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