| 名称 | Rabbit Anti SN38 Antibody, mAb |
| 类型 | Monoclonal |
| 免疫宿主 | Rabbit |
| 免疫原 | SN38 conjugated to keyhole limpet haemocyanin(KLH) |
| 亚型 | IgG |
| 纯化方法 | Purified by Protein A |
| 特异性 | This antibody recognizes SN38 and SN38 structurally similar molecules. |
| 验证应用平台 | ELISA |
| 缓冲液 | 1×PBS, pH7.4, containing 0.1% BSA, 50% glycerol and 0.03% Proclin 300. |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
| 应用 | ELISA |
| 推荐用量 | 0.1-2 µg/ml |
Rabbit Anti SN38 Antibody, mAb binds with BSA-SN38 conjugate. Coating antigen: BSA-SN38 conjugate, 1 µg/ml，100 µl/well. Rabbit Anti SN38 Antibody, mAb dilution start from 1000 ng/ml.EC50= 16.2 ng/ml.
Standard curve of SN38 Competitive ELISA. The competitive ELISA assay is developed by using free SN38 block the binding of Rabbit Anti SN38 Antibody, mAb to BSA-SN38 conjugate. Coating antigen: BSA-SN38 conjugate, 1 µg/ml，100 µl/well. Detection Antibody: Rabbit Anti SN38 Antibody, mAb,100ng/ml 50ul/well. Free DXd dilution start from 10000 ng/ml,50ul/well.
SN-38 is a highly attractive yet challenging cytotoxic payload. It is a potent topoisomerase I inhibitor, 100-1000 times more active than its prodrug irinotecan. However, its extreme hydrophobicity causes aggregation and pharmacokinetic issues in ADC development. To overcome this, novel linker technologies and soluble prodrug forms (e.g., CL2A-SN-38) have been engineered. These innovations enable the effective delivery of SN-38 directly to tumor cells via antibody targeting, maximizing its anticancer efficacy while minimizing systemic toxicity. ADCs like sacituzumab govitecan successfully leverage this strategy.
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