| 名称 | Rabbit Anti DXd Antibody, mAb |
| 类型 | Monoclonal |
| 免疫宿主 | Rabbit |
| 免疫原 | DXd conjugated to keyhole limpet haemocyanin(KLH) |
| 亚型 | IgG |
| 纯化方法 | Purified by Protein A |
| 特异性 | This antibody recognizes DXd and DXd structurally similar molecules. The antibody can bind to DS-8201. |
| 验证应用平台 | ELISA |
| 缓冲液 | 1×PBS, pH7.4, containing 0.1% BSA, 50% glycerol and 0.03% Proclin 300. |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2-8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
| 应用 | ELISA |
| 推荐用量 | 0.1-2 µg/ml |
| DTA0299 | |
| EC50 | 3.39 ng/ml |
Rabbit Anti DXd Antibody binds with BSA-DXd conjugate.
Coating antigen: BSA-DXd conjugate, 0.1 µg/ml，100 µl/well.
Rabbit Anti DXd Antibody dilution starts from 1000 ng/ml.
The competitive ELISA assay is developed by using free DXd block the binding of Rabbit Anti DXd Antibody to BSA-DXd conjugate.
Coating antigen: BSA-DXd conjugate, 0.1 µg/ml, 100 µl/well.
Detection Antibody: Rabbit Anti DXd Antibody, 100ng/ml 50ul/well.
Free DXd dilution start from 10000 ng/ml.
DXd is a cell microtubule dynamics inhibitor and a soft sponge like anti-tumor drug. ADC loaded with DXd has a strong bystander effect and good clinical efficacy. Due to the release of payload after ADC administration, there is an increase in unbound payload and changes in ADC composition (i.e. DAR distribution). In order to address the challenges and difficulties in ADC drug PK analysis, a high-quality and high affinity anti DXd payload antibody can be used for ADC PK detection and DAR value analysis, which helps evaluate ADC efficacy, assess payload exposure at target sites, and is crucial for providing overall evaluation such as ADC stability.
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