| 类型 | Monoclonal |
| 特异性 | This antibody recognizes CD25 molecules. |
| 免疫宿主 | Mouse |
| 亚型 | IgG |
| 纯化方法 | Purified by Protein A |
| 验证应用平台 | Flow Cyt |
| 状态 | Liquid |
| 缓冲液 | PBS,pH7.4 |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2 -8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
CD25, also known as IL-2 receptor α chain (IL-2Rα), is a key component of the interleukin-2 receptor (IL-2R) complex. It is primarily expressed on activated T cells, regulatory T cells (Tregs), and some dendritic cells. As a low-affinity receptor for IL-2, CD25 alone binds the cytokine with weak affinity, but upon ligand engagement, it facilitates the recruitment of CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form a high-affinity ternary receptor complex. This structural reorganization enhances IL-2 signaling, which is essential for T-cell proliferation, differentiation, and immune regulation. In clinical contexts, CD25 serves as a biomarker for activated T cells and Tregs, and is a target in therapies for autoimmune diseases and certain cancers.
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