Anti-CD45RO Antibody, mAb

产品名称	Anti-CD45RO Antibody, mAb
产品货号	DTA0655
产品规格
价格

产品详情

类型	Monoclonal
特异性	This antibody recognizes CD45RO molecules.
Clone号	UCHL1
免疫宿主	Mouse
亚型	IgG
纯化方法	Purified by Protein A
验证应用平台	Flow Cyt / IHC
状态	Liquid
缓冲液	PBS，pH7.4
储存方式	Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2 -8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles.

产品说明书产品说明书

CD45RO is an isoform of the CD45 (leukocyte common antigen) molecule, which lacks exons 4, 5, and 6 in its extracellular domain due to alternative splicing. As a single-pass transmembrane glycoprotein with intracellular protein tyrosine phosphatase (PTPase) activity, CD45RO functions as a critical regulator of T cell receptor (TCR) signaling by modulating the activity of Src-family kinases such as Lck.

This isoform is predominantly expressed on the surface of activated and memory T cells, distinguishing them from naïve T cells, which typically express CD45RA. The switch from CD45RA to CD45RO expression occurs upon antigen-driven T cell activation and is associated with enhanced responsiveness and effector function. As a result, CD45RO serves as a widely used phenotypic marker for identifying and isolating memory T cell populations in both research and clinical immunology, particularly in the context of infectious diseases, autoimmune disorders, and vaccination studies. Its expression pattern also makes it a relevant indicator in monitoring immune activation and memory formation in various physiological and pathological conditions.

物流平台：默认为京东物流。若有其他需求，请联系对接销售。
发货时间：确认订单并完成付款后1~2个工作日内安排发货。
发货方式：冰袋或干冰。