| 类型 | Monoclonal |
| 特异性 | This antibody recognizes HOX40L molecules. |
| Clone号 | 159403 |
| 免疫宿主 | Mouse |
| 亚型 | IgG |
| 纯化方法 | Purified by Protein A |
| 验证应用平台 | Flow Cyt |
| 状态 | Liquid |
| 缓冲液 | PBS,pH7.4 |
| 储存方式 | Shipped in ice bag. The antibody can be stored for 1-2 weeks at 2 -8°C. For long term storage, store it at -20°C. Avoid repeated freezing and thawing cycles. |
HOX40L (also known as TNFRSF4 ligand or CD252) is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on antigen-presenting cells such as dendritic cells, B cells, and macrophages. As the ligand for OX40 (CD134, TNFRSF4), HOX40L plays a critical role in T-cell costimulation and immune regulation. Upon binding to OX40 on activated T cells, it enhances T-cell proliferation, survival, cytokine production, and the formation of memory T cells. This interaction is particularly important for sustaining effector and memory T-cell responses in infections, antitumor immunity, and autoimmune inflammation. Given its function in modulating adaptive immunity, HOX40L has emerged as a promising target in immunotherapy, with ongoing research focused on agonistic or antagonistic strategies to enhance antitumor responses or treat autoimmune and inflammatory disorders.
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